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    dcyphr-d by Leanna Zelle on 2020-06-18
    Abstract Normal mice, as well as knockout mice for platelet endothelial cell adhesion molecule (PECAM-1 -/-) and endothelial NO synthase (eNOS-/-) mice were tested to see how their vessels responded to histamine. Histamine increased vessel dilation and then vessel constriction in the normal and PECAM-1 -/- mice, but the eNOS -/- mice had only constriction. Several agonists and antagonists were tested in each different mice. The results show that the response of vessels to histamine is regulated ...
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    dcyphr-d by Janet Hsu on 2020-06-18
    Aims In this letter to the editor, the authors aim to predict the total number of COVID-19 cases and deaths in Brazil by January 2021. Introduction As of August 19, 2020, Brazil has already had more than 300 million COVID-19 cases. The number of deaths is past 100,000 with a case fatality rate of 3.2%. Case fatality rate is the percentage of patients that pass away due to a disease compared to the total number of cases. The case fatality rate is likely an underestimate because researchers canno...
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    dcyphr-d by Daniel Amuedo on 2020-06-18
    AbstractScientists have found that the COVID-19 virus binds to the angiotensin-converting enzyme 2 (ACE2) receptor to enter the cell. This study looks at how much ACE2 receptor is contained in the Central Nervous System (CNS) tissue. The ACE2 receptors in the CNS show if COVID-19 damages nervous tissue. BackgroundCOVID-19 and GeneticsThe entire genome analysis of COVID-19 showed it was an RNA virus. This test also showed that COVID-19 was found before in bats in China. ACE2...
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    dcyphr-d by Alexander Alexandrov on 2020-06-18
    Abstract This is a statement from the Indian Heart Rhythm Society (IHRS) summarizing the cardiovascular effects of hydroxychloroquine. The primary effects discussed are QT interval prolongation (heart taking too long for electrical recharge) and potentially fatal arrhythmia (irregular heartbeat). This paper also addresses methods of identifying high risk groups and the monitoring necessary to prevent cardiac related death.  Introduction Hydroxychloroquine is often used for “autoimmune disorders,...
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    dcyphr-d by Christina Hijiya on 2020-06-18
    Abstract Researchers looked for vaccine targets against COVID-19 by investigating genetic similarities between SARS-CoV-2, the virus that causes COVID-19, and SARS-CoV, which caused a major outbreak in 2003. The researchers identified B cell and T cell epitopes in the S and N proteins that are identical between the two viruses. For T cell epitopes, the researchers also calculated the percentage of the global and Chinese population that could be covered by vaccines that target these epitopes. The...
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    dcyphr-d by Christina Hijiya on 2020-06-18
    Abstract In this study, the researchers analyzed the unrest that occurred in Chile in 2019 through the lens of an epidemic-like mathematical model. They adjusted the conditions of the model using data about the unrest, and observed that the number of violent events follow well-defined patterns of social unrests that have been observed in other countries since the 1960s. The researchers also added disturbances to the model that alters the model to mimic the chaotic nature of the 2019 Chilean soc...
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    dcyphr-d by Oby Uche on 2020-06-18
    Abstract:COVID-19 is an acute respiratory tract infection. Understanding where exactly the SARS-CoV-2 virus replicates and infects within the body is important in trying to contain the virus. The paper reports, based on review of nine cases, that the SARS-CoV-2 virus can replicate in upper respiratory tract tissues. Active replication in the throat was confirmed by the presence of viral replicative RNA in throat samples. Significant amounts of virus can still be found in the sputum (phlegm) of p...
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    dcyphr-d by Janet Hsu on 2020-06-18
    IntroductionThe novel coronavirus, SARS-CoV-2, is causing the COVID-19 pandemic. Many of the common symptoms of the coronavirus include cough, fever, headache, soreness, and more. In Spain, dermatologists have been treating patients virtually. The researchers noted an increasing number of cases of lesions that resemble chilblains. Chilblains are skin sores that show up when small blood vessels become inflamed from the cold. The majority of patients were children or young adults. They initially h...
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    dcyphr-d by Christina Hijiya on 2020-06-18
    Abstract Racial disparities in pain management have been previously documented. Further understanding of the causes of these disparities is needed to make healthcare provision equitable. In this study, the researchers wanted to understand racial differences in how analgesia is administered in children with appendicitis. Analgesia are drugs that relieve pain. They paid special attention to the administration of opioids. This study was a repeated, observational study of patients less than 21 years...
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    dcyphr-d by Katerina Christopoulou on 2020-06-18
    Letter to the EditorCOVID-19 is a new infectious disease, which was declared as a pandemic, causing a global public health emergency. This is related with the SARS-CoV-2's high contagiosity and quick transmission.Previous studies mainly focused on epidemiological characteristics and prevention of COVID-19, while few studies looked on the duration of SARS-CoV-2 carrying in COVID-19 patients. According to the sceintists, learning more about the SARS-CoV-2 carrying duration, the time of infection, ...