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dcyphr | Biochemistry
Biochemistry

Research concerning the chemical processes of living organisms. Includes articles from Yale BIOL 101 class.

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    dcyphr-d by Clare McGarry on 2020-06-18
    AbstractBraun et al. tested the effect of cytokeratin-positive cancer cells on the development of breast cancer. The authors extracted bone marrow aspirates from the upper iliac crests of patients, with stage I, II, or III breast cancer, who had the tumor removed. Bone marrow aspirates were also extracted from non-cancerous controls. The aspirates were stained with a monoclonal antibody, A45-B/B3, which is bound to antigens on cytokeratins. Follow up appointments ranged from 10-70 months and th...
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    dcyphr-d by Leanna Zelle on 2020-06-18
    AbstractThis study looks at the expression of endoglin (CD105), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR-1), and epidermal growth factor receptor 2 (c-erbB-2). The expression of these were all correlated with the prognosis of adenocarcinoma in the cervix. This study shows that cervical adenocarcinoma is caused by angiogenesis that is controlled by the interactions of CD0105, VEGF, EGFR-1, and c-erbB-2. IntroductionCervical cancer has been decreasing in wo...
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    dcyphr-d by Janet Hsu on 2020-06-18
    AimsThe authors aim to analyze characteristics and outcomes of patients with COVID-19. They analyzed the New York City Area to further understand the outbreak in the United States.IntroductionThe first COVID-19 outbreaks in the United States were in Washington State and California. Now, the United States has more infections than in Italy and China combined. New York City has the greatest population density, so New York has more than 30%% of the cases in the United States. New York also has mor...
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    dcyphr-d by Leanna Zelle on 2020-06-18
    AbstractThis study aims to see changes in protein expression in NIH 3T3 cells treated with virgin coconut oil (VCO) and hydrolysed virgin coconut oil (HVCO). The cells were treated with either nothing, VCO, or HVCO. Then each of those conditions were analysed to look for changes of expression in MMP-9, PDGF-BB, or TGF-beta1. Both VCO and HVCO increased the expression of all three proteins tested, with HVCO increasing the values by a higher factor. This data tells us that coconut oil is active in...
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    dcyphr-d by Janet Hsu on 2020-06-18
    AbstractThe drug BI-RG-587 inhibits HIV-1 reverse transcriptase. It is noncompetitive with respect to dGTP. BI-RG-587 inhibited HIV-1 replication in vitro. BI-RG-587 showed little cytotoxic effects until very high concentrations in culture.Introduction Many drug therapies for HIV-1 target the reverse transcriptase because reverse transcriptase is needed for virus replication. Reverse transcriptase is an enzyme that generates DNA from an RNA template. Many effective inhibitors are nucleoside anal...
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    dcyphr-d by Janet Hsu on 2020-06-18
    AbstractThere are many existing hypotheses for the mechanism of DNA replication. There are three main models. The conservative model states that the parent DNA molecule remains completely intact. New DNA molecules are made of completely new strands. The semiconservative model states that each new DNA has one new strand and one parent strand. The dispersive model states that fragments of the parent are randomly passed on.Previous experiments used radioisotope labels to study DNA. In this experime...
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    dcyphr-d by Leanna Zelle on 2020-06-18
    Abstract Bronchopulmonary dysplasia (BPD) is a fatal lung disorder that happens when the alveoli of infants stop developing normally. Using mechanical ventilation on infants can cause BPD. The microvessels around the alveoli are also developed in BPD. This study aims to identify different factors important to angiogenesis in infants who have been put on mechanical ventilation. This research team found high levels of Endoglin in the microvessels and low levels of vascular endothelial growth facto...
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    dcyphr-d by Leanna Zelle on 2020-06-18
    Abstract Patients with cardiovascular disease and inflammation have high levels of soluble endoglin in their blood. Mice expressing human soluble endoglin (sEng+) were put under different inflammatory conditions. sEng+ mice has reduced lung and kidney injury after inflammation. There were also lower levels of neutrophils in inflamed lungs and kidneys. The sEng+ mice also had less proinflammatory cytokines, like TNF-alpha, IL1-beta, and IL6 compared to the wildtype mice. Cell adhesion molecules l...
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    dcyphr-d by Leanna Zelle on 2020-06-18
    Abstract Since the rapid growth of microvessels can increase plaque in patients with carotid stenosis, it is important to identify a maker for microvessels. CD31 and CD105 are the possible markers studied in this experiment, and it turns out that CD105 is better for detecting microvessels in plaque. Aims This study aims to determine if CD31 or CD105 is a better marker for microvessels. Introduction Finding a good marker for carotid plaques is really important for the treatment of carotid stenosi...
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    dcyphr-d by Vincent Lam on 2020-06-18
    AbstractThis is a phase three clinical trial in which the authors of this paper are testing the outcomes of giving the antibody, ipilimumab, to patients who had stage III melanoma tumors successfully removed. The dose of ipilimumab in this trial is 10 mg per kg of body weight. The patients examined in this study were randomly assigned to receive either ipilimumab or placebo. The survival, recurrence rates, and distant metastasis rates of these two groups were measured about 5.3 years after the s...